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Effects of Adding L-BAIBA to Exercising Adult Overweight Men and Women ...

Effects of Adding L-BAIBA to Exercising Adult Overweight Men and Women ...

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Effects of Adding L-BAIBA to Exercising Adult Overweight Men and Women on Changes in Body Composition, Glucose Control, and Cardiometabolic Risk Factors

LU IRB#: IRB-23-29
PI: Chad Kerksick, PhD

Description of Study

The purpose of this study is to examine changes in body composition, fasting glucose, perceptual indicators of hunger and appetite, and profile of mood state after adding supplementation of BAIBA to exercise in overweight and obese men and women.

Location
Exercise and Performance Nutrition Laboratory (Fieldhouse 126)
209 S Kingshighway St
Saint Charles, MO 63301

Number of Visits
4

Time Commitment
Visit 1: 45 minutes
Visits 2-3: 75 minutes each
Visit 4: 90 minutes

Compensation
$300 (Direct Deposit)

Points of Contact
Paige Sutton and Joesi Krieger
epnl@lindenwood.edu

Research Sample Needed

  • 120 healthy overweight or mildly obese men and women.

Inclusion Criteria

  • Participants who are between 18 – 60 years of age.
  • Body mass index values will range from >25.0 to < 32.0 kg/m2, making them qualified as an overweight-to-obese population.
  • Average body mass index for entire study cohort will be less than 30.0 kg/m2. As such an ongoing calculation of the recruited cohort’s mean body mass index will be maintained and people will only be randomized into the study if the average cohort body mass index value does not exceed 30.0 kg/m2.
  • Free-living/uninhibited with use of ambulatory assistive devices (e.g. canes, crutches, walkers, etc.) and independent.
  • In good health absent of being overweight or mildly obese with no other signs or symptoms of cardiovascular, respiratory, metabolic, immune, psychiatric, or musculoskeletal disease or disorders.
  • Willingness to maintain consistent sleep duration the evening before study visits.
  • Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, and carry out all study-related procedures.
  • Able to complete a peak oxygen consumption exercise test with no contraindications to perform exercise per standards put forth by the American College of Sports Medicine. In other words, they are able to safely complete maximal exercise.

Exclusion Criteria

  • Positive medical history and/or is currently being treated for some form of heart disease, cardiovascular disease, neurological condition/disease.
  • Current treatment for kidney disease, renal failure, or has dialysis performed on regular intervals.
  • Liver disease or some form of clinically diagnosed hepatic impairment.
  • Diagnosed with Type I or Type II diabetes (determined as fasting blood glucose > 126 mg/dL).
  • Diagnosed with or is being treated for some form of thyroid disease.
  • Diagnosed with major affective disorder or other psychiatric disorder that required hospitalization in the prior year.
  • Diagnosed with some form of immune disorder (i.e., HIV/AIDS).
  • History of cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit).
  • Has an abnormality or obstruction of the gastrointestinal tract precluding swallowing (e.g., dysphagia) and digestion (e.g., known intestinal malabsorption, celiac disease, inflammatory bowel disease, chronic pancreatitis, steatorrhea).
  • Currently prescribed a statin drug (i.e., Lipitor, Livalo, Crestor, Zocor, etc.) or hypertension medication (i.e., Beta-blockers, ACE Inhibitors, Alpha blockers, Vasodilators, etc.).
  • Current smoker (average of > 1 pack per day within the past 3 months) or has quit within the past six months. This includes all forms of nicotine.
  • Intake of any drugs (prescribed or over the counter) or dietary supplements that are known or are purported to weight loss such as thermogenics, hydroxycitric acid, ephedra, capsaicin, etc.
  • Participants who are lactating, pregnant or planning to become pregnant.
  • Have a known sensitivity or allergy to any of the study products.
  • History of alcohol or substance abuse in the 12 months prior to screening.
  • Receipt or use of an investigational product in another research study within 30 days of beginning the study protocol.
  • They plan major changes in lifestyle (i.e., diet, dieting, exercise level, travel, etc.) during the study.
  • Recent history (<3 months) of exercise training or weight loss (> 5%).
  • Any orthopedic limitation that would prevent participation in a general fitness program.

Are You Eligible?

Information provided here reflects current IRB approval for this research. However, this information may be subject to change and updated accordingly.

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